Mefenamic acid instructions for children. Mefenamic acid. Come in safely during zastosuvanni

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Mefenamic acid (group NPZZ) - zasіb, sho Nadaє protizapalny, sedative and antipyretic diї.

Pharmacological activity

Mefenamic acid is a non-steroidal anti-inflammatory drug treatment. Data on the power of the drug are associated with inflammation mediators (prostaglandins, kinin in the skin), as well as a decrease in the activity of lysosomal enzymes, which take a part in the ignition processes.

Crimson, mefenamic acid stabilizes the action of protein ultrastructures and clitin membranes, changes the penetration of vessels, enhances the synthesis of mucopolysaccharides, increases the resistance of clitin, and also heals wounds.

The antipyretic power of the drug is associated with the development of galvanic synthesis of prostaglandins, thereby influencing the thermoregulation center. Mefenamic acid reacts with the dissolved interferon.

The drug is injected into the middle of the inflammation, with the help of the galmui, the algogens (histamine, serotonin) are dissolved. After accepting the doctor's order, it will be wetted quickly grass path. The maximum concentration in the blood is observed in 2-4 years after taking the drug. According to the instructions, mefenamic acid is excreted in the body (become 67 times a day per dose), as well as with faeces (become 20-25 times a day per dose).

Method of stoking and dosing

The drug should be taken orally.

We grow up, and also for children over 12 years of age, they prescribe 250-500 milligrams, 3-4 times a day. In order to ensure good tolerability of the drug, the additional dose can be increased to 3000 mg (given the maximum dose). Once a therapeutic effect has been achieved, the dose will be reduced to 1000 milligrams per dose.
For children who are between 5 and 12 years of age, prescribe 250 mg, 3-4 times a day.

Mefenamic acid for children, as well as older adults, should be taken with milk. The course of likuvannya can take up to two or more months. With the treatment of the painful syndrome, the duration of the treatment becomes 7 days.

Indication before zastosuvannya

Mefenamic acid for children and adults is prescribed in such cases:

Like a person has a hostile respiratory infection.
Bil: m'yazovy, suglobovy, toothy, smutty, pyslyapologovy, and also postoperative.
The drug is prescribed for primary dysmenorrhea. Dysfunctional menorrhagia, caused by the presence of intrauterine contraceptives, due to the presence of pathology of the pelvic organs.
Assign in case of ignition diseases of the musculoskeletal apparatus.
Rheumatism, ankylosing spondylitis, rheumatoid arthritis.

Contraindication to congestion

According to the instructions, mefenamic acid was not indicated in the onset of depression:

How can a person be afraid of hypersensitivity to the components of the drug.
With virazkovy ailment, the slough and twelve-fingered intestines.
With chronic illnesses duct-intestinal tract.
With ailments, nirok, as well as with internal bleeding.
Mefenamic acid is categorically prevented from congestion during pregnancy and during lactation.

especially vkazіvki

According to the instructions, mefenamic acid should be reserved for people who may have allergic reactions to acetylsalicylic acid and other non-steroidal anti-inflammatory speech.

Krym tsgogo likarsky zasіb z proberezhnіstyu appoint ailments, those who have heart failure, as well as patients who suffered in the anamnesis of Viraz's ailment of the tuber or duodenal intestine.

Mefenamic acid in children less than 5 years of age is contraindicated before congestion.

Zastosuvannya with vagity and lactation

Mefenamic acid is contraindicated before the stagnation of vagit women through the temporal hemorrhage of the anterior closure of the botal duct. If necessary, the drug can be used during the period of breastfeeding, but baby shower next pin.

Overdose

In times of overdose, the following symptoms are blamed:

Severe pain in the epigastric cavity.
Vomiting, boredom, drowsiness.
In severe depressions, there is mucosal-intestinal bleeding, difficulty in breathing, arterial hypertension, and also coma.

As a work of exaltation: a specific antidote of Mefenamic acid and daily. It is necessary to wash the hose with a suspension activated vugill.

Side effects

May be blamed for flatulence, vomit, liver, nausea, constipation, diarrhea from the side of the intestinal tract.
Arrhythmia, arterial hypertension, peripheral swelling - the cardiovascular system.
Bronchospasm - from the side of the dichal system.
Podovzhennya hour of bleeding, leukopenia - from the side of the blood.
Cystitis, polyuria, albuminuria - from the side of the siechovivid system.
Sleeplessness, weakness, drativity - from the side nervous system.
Damage to the dawn - from the side of the organs a little. Damn it, the patient can blame the noise in the wahs.
Nabryak disguise, hanging on the shkіrі, sverbіzh shkіri - allergic reactions.

Wash that term saving

Wash your mind: the temperature is not higher than 25 degrees. Celsius, to prevent the drug from getting into the child's hands.

The term of appurtenance - 2 years.

Having pressed two tabs, change it below.

One of the most common symptoms that accompany more ailments is bil. Yakshto bіl becomes unbearable, it means that it is inflamed, and it's a blur. With these unacceptable symptoms, mefenamic acid may occur. This preparation of vicorist is not only for the relief of symptoms of an ailment, but also for treating the symptoms of a musculoskeletal apparatus.

____________________________

Warehouse of power

Mefenamic acid is produced in the form of tablets, which include:

The active speech is mefenamic acid.

Mefenamic acid is brought to non-steroidal anti-inflammatory and anti-rheumatic effects, and may come to power:

Additional speech - methylcellulose; starch; magnesium stearate; sodium croscarmellose; ocatedecanoic acid.

Indications and contraindications

Indications before the stagnation of mefenamic acid is also ill or damaged:

In addition, the drug vicorist is used as an antipyretic drug in case of fever. If a woman is planning to take care of herself, if she is too tired to take the drug, shards of wine can disrupt her fertility.

Contraindications before the ingestion of mefenamic acid:

Vagіtnіst that anniversary of the breast.
Children's age up to 5 years.
Blood poisoning.
Virazkov's ailment of the twelve-fingered intestine.
Ignition processes of the shlunkovo-intestinal tract.
Damaged functions of the liver and liver.
Gastritis.
Cirrhosis of the liver.
Heart failure.
Allergic reaction to a component of the drug.

Mefenamic acid reduces the speed of the reaction, so it is not recommended for the person to drive during the period. With care, the drug is prescribed for epilepsy or heart disease.

Installation instructions

Method of stosing and dosing Mefenamic acid to deposit according to the patient's needs:

To change the possible teasing of the mucous membrane of the slough, the drug can be taken every hour.

Overdose, side reactions

In case of a violent overdose of the drug, the following symptoms can be blamed, in which case it is negligently turned to the doctor:

Likuvannya transfer symptomatic therapy, forcing diuresis, washing the drain. Mefenamic acid is highly bound to blood proteins, so hemodialysis is not effective.

Overdose cream, possible rare manifestation of side reactions to the drug:

Discomfort in the intestinal tract.
Bіl at the intestines that slug.
Shlunkovo-intestinal bleeding.
Rarely a development of visor.
Purpura.
Tricks.
Disturbed heart rhythm.
Advancement of arterial pressure.
Show dizurichni.
Damaged functions of nirok.
Agranulocytosis.
Eosinophilia.
Hematuria.
Drativity.
Sleep disruption.
Shkirny visip.
Kropivnitsa.

If you show any adverse reactions, do not take the decision on your own, respectfully and negligently turn to the doctor, or call for help.

Video

Pharmaceutical form

Walkers.

The main physical and chemical authorities: tablets of a grayish-white color with a slightly yellowish or greenish appearance, flat-cylindrical shape, with a chamfered rib, marmur is allowed.

Pharmacological group

Non-steroidal anti-inflammatory and anti-rheumatic diseases. Fenamat.

Code Atx М01А G01.

Pharmacological authorities

Pharmacodynamics.

Mefenamic acid is a non-steroidal antiseptic drug. The mechanism of anti-inflammation of inflammation to increase the synthesis of inflammation mediators (prostaglandins, serotonin, kinin and others), reduce the activity of lysosomal enzymes, which take part in the inflammation reaction. Mefenamic acid stabilizes the protein ultrastructure and cell membranes, changes the penetration of vessels, disrupts the processes of oxide phosphorylation, inhibits the synthesis of mucopolysaccharides, galmuic proliferation of cells in the inflammation cavity, promotes resistance to inflammation and wounds. Fever-lowering power causes galvanic synthesis of prostaglandin and influx on the thermoregulation center.

Mefenamic acid stimulates the release of interferon.

In the mechanism of pain relief, in order of influx on the central mechanism of pain sensitivity, the primary role in playing the muscles is infused in the middle of the inflammation and the building of the galmuvate of the elimination of algogens (kini, histamine, serotonin).

Pharmacokinetics.

After taking internally mefenamic acid, it is easy to drink and soak thoroughly in the herbal tract. The maximum concentration in the blood is observed after 2-4 years after taking. Riven in the blood is a proportional dose. Equally important concentration (20 mcg / ml) is assigned for 2 doses of ingestion (1 g 4 times per dose). Contacted by 90% of blood albumin. In the liver, it metabolizes by way of oxidation, hydrolysis, glucuronidation. The period of drinking (T 1/2) is 2-4 years. It is important to excrete in the body in the unchangeable form in the presence of metabolites, most importantly in the form of drugs (67% of the dose), with faeces (20 - 25%).

Indication

Acute respiratory viral infections and influenza.

Pain of low and medium intensity: m'yazovy, suglobovy, traumatic, dental, head pain of different etiology, post-operative and post-slyapological pain.

Primary dysmenorrhea. Dysfunctional menorrhagia, including due to the presence of intrauterine contraceptives, due to the presence of pathology of the pelvic organs.

Illumination of the musculoskeletal apparatus: rheumatoid arthritis, rheumatism, Bechter's disease.

Contraindication

Increased sensitivity to the components of the medical care. Bronchospasm, angioedema, rhinitis, bronchial asthma or a history of croup, due to the accumulation of acetylsalicylic acid or other non-steroidal anti-inflammatory diseases (NPZZ). One-hour intake of specific COX-2 inhibitors. Virazkov's ailment of the slough and twelve-fingered intestines, including those in the anamnesis, fuses intestines, ailment of hematopoietic organs, severe heart failure, severe damage to the liver function of an organ, slutal-intestinal bleeding or perforation, caused by non-steroidal anti-inflammatory diseases.

Interactions with other medical procedures and other types of interactions

Thiamine, pyridoxine hydrochloride, barbiturates, similar phenothiazines, narcotic analgesics, caffeine, diphenhydramine promote the analgesic effect of the drug treatment.
With total congestion of mefenamic acid methotrexate the toxic effects of methotrexate are exacerbated.

Antihypertensive drugs (ACE inhibitors and angiotensin II receptor antagonists): decreased antihypertensive effect, increased risk of nirk deficiency, especially in patients of a frail age. Patients are guilty of living enough home. It is also necessary to evaluate the function of nirok on the cob of cob and during concomitant therapy.

Diuretics: reduction of the sechoginal effect. Diuretics may increase the nephrotoxicity of NSAIDs.

Heart glycosides: NSAIDs can alleviate heart failure, change glomerular filtration rate, and increase the level of cardiac glycosides in blood plasma.
Cyclosporine: increased risk of developing nephrotoxicity.

Mifepristone: The NPSH should not be taken for 8-12 days after taking mifepristone - the NPSH may reduce the dose of mifepristone.

Corticosteroids: increase in the development of the rhizomes of the slunic-intestinal veins and bleeding.

Antiaggregant and selective inhibitors of serum ingestion of serotonin: increase in the risk of shlunkovo-intestinal bleeding.

Fluoroquinolones: NPZZ advance risk development by the court.

Aminoglycosides: NPZZ raises the risk of developing a nephrotoxic effect.

Tacrolimus: it is possible to increase the risk of developing a nephrotoxic effect.

Zidovudin: NSAIDs increase the risk of developing hematological toxicity. There is a risk of hemorrhage in the globule and hematomas in VIL-positive ailments for hemophilia, and they are immediately treated with zidovudine.

Preparations of lithium: decrease in lithium exposure and increased risk of lithium toxicity.
Mefenamic acid promotes activity oral anticoagulants to that, with their one-hour stasis, there is a risk of bleeding. One-hour infusion of mefenamic acid with oral anticoagulants requires control of the prothrombin hour. The next step is to take special precautions with NPZZ with warfarin or heparin - a necessary medical precaution.

One-hour zasosuvannya other non-steroidal anti-inflammatory measures leading to an antiseptic effect and the occurrence of side effects on the side of the intestinal tract.

Features

Likarskiy zasib with care, we prescribe illness for the presence of acute heart failure, arterial hypertension, ischemic disease heart.

The medical zasіb z zaberezhnіstyu prescribe ailments for epilepsy.

Do not ingest mefenamic acid in patients who have previously experienced hypersensitivity reactions, for example, asthma, bronchospasm, rhinitis, angioedema, or cropidation.

Do not zastosovuvaty znevodnenim patients, yakі squandered the motherland in the aftermath of vomiting, diarrhea, or advanced sechoviprosy.

With a trivial headache, you should consult a doctor.

When the liver functions are damaged, there are no special recommendations for stopping the medical treatment.

NPZZ should take care of patients who may have a history of ailment of the intestinal tract (virazkovy kolіt, Crohn's disease), shards of the disease can be aggravated. As a result of the congestion of mefenamic acid, it has led to mucosal-intestinal bleeding and perforation, it is necessary to administer it.

Patients of a frail age may develop a risk of development. side effects from the side of the duct-intestinal tract, especially the duct-intestinal bleeding and perforation, which can lead to death, this needs to be started with the least dosing.

Patients with systemic vermicompost and diseased healthy tissues may develop a risk of aseptic meningitis.

Mefenamic acid should be reserved for patients with high risk due to serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. It is necessary to take mefenamic acid in case of the first appearance of hanging on the skin, loose mucous membrane, or in case of any other manifestation of hypersensitivity.

At trivial zastosuvanni It is necessary to carry out monitoring of blood indicators in the medical care, shards of mefenamic acid can cause pathological changes in the side of the blood. In case of manifestations of any dyscrasia, it is necessary to apply the therapy with medical care.

The use of mefenamic acid can lead to disruption of the intestinal tract (for example, diarrhea). The stench can be blamed immediately after the stagnation of the medical care, so after the tribal reception. As such symptoms are winickly, it is necessary to take medical care.

It is necessary to be careful in case of mefenamic acid stasis in patients, in order to avoid therapy with drugs, in order to reduce the risk of bleeding: corticosteroids, anticoagulants (warfarin) and aspirin.

The intake of mefenamic acid can lead to the destruction of female fertility and is not recommended for women, as it may cause damage. In case of zastosuvanni women with symptoms of dysmenorrhea and menorrhagia and the presence of a likuval effect, it is necessary to turn to the doctor.

Congestion during pregnancy or breastfeeding

The medical zasib should not stop women during the period of pregnancy and breastfeeding.

Zdatn_st vplivat on swidk_st reaction when keruvannya by motor transport by other mechanisms

Be careful when caring for motor transport or robots with mechanisms that require increased respect, shards and other zastosuvannya likarskogo zasobu can call for drowsiness, illegibility of dawn, judgment.

Method of stosuvannya that dose

Zastosovuvati likarsky zasib following the sight of a doctor, which determines the dose and the trivality of the likuvannya. Stop internally. Likarskiy zasіb slid to take after you go, drinking milk.

Let's grow up and children over 12 years old prescribe 250 - 500 mg 3 - 4 times a day. For indications, and with good tolerance, the additional dose should be increased to a maximum of 3000 mg, after reaching a therapeutic effect, the dose should be reduced to 1000 mg per dose.

For children from 5 to 12 years old- 250 mg 3 - 4 times a day.

The course of healing in case of ill-healthy swamps can be taken from 20 days to 2 months and more. With the treatment of pain syndrome, the course of treatment is continued up to 7 days.

Children

Lіkarskiy zasіb contraindications for children up to 5 years of age.

Overdose

Symptoms: pain in epigastric dilatation, boredom, vomiting, drowsiness. In severe depressions - sloughing-intestinal bleeding, dyspnoea, arterial hypertension, mimicking of other groups of mucus, coma.

Likuvannya. Specific antidote daily. Washing the sluice with a suspension of activated water. Pіdluzhuvannya section, forcing diuresis. Symptomatic therapy. Hemosorption and hemodialysis are of little effect due to the microbinding of mefenamic acid with blood proteins.

Side effects

From the side of the organization gap: ruined by the dawn, the reverse cost of the building of the diversity of colors, the teasing of the eyes.

From the side of the organs of hearing and the vestibular apparatus: dzvіn vuhah, otalgіya.

From the side of the respiratory system, the organs of the chest and the middle wall: dyspnea, bronchospasm.

From the side of the shlunkovo-intestinal tract: epigastric dilatation, anorexia, liver pain, nausea, flatulence, vomiting, enterocolitis, colitis, acute colitis and Crohn's disease, gastritis, hepatotoxicity, steatorrhea, cholestatic zhovtyanitsy, hepatitis, pancreatitis, hepatorenal syndrome. Ductal-intestinal bleeding, perforation or slu- chal-intestinal bleeding, sometimes fatal, especially in patients with a frail age, dyspepsia, constipation, diarrhea.

From the side nirok ta sechovivid system: dysuria, cystitis. Impaired nitrofunction, albuminuria, hematuria, oliguria or polyuria, nirk deficiency, including papillary necrosis, hostria interstitial nephritis, nephrotic syndrome, allergic glomerulonephritis, hyponatremia, hyperkalemia.

From the side of the nervous system: drowsiness or insomnia, weakness, drativity, agitation, headaches, clouding of the eyes, sudomi, neuritis of the zore nerve, paresthesia, confusion, rigidity of the fever, lihomania, inversion of orientation. From the side of the psyche Key words: confusion, depression, hallucinations

From the side of the cardiovascular system: arterial hypertension, arrhythmia, rarely - congestive heart failure, peripheral swelling, insomnia, arterial hypotension, heartbeat, buttocks, thrombotic aggravation (for example, myocardial infarction or stroke).

On the side of the blood lymphatic system: aplastic anemia, autoimmune hemolytic anemia, increased bleeding time, eosinophilia, leukopenia, thrombocytopenia, decreased hematocrit, thrombocytopenic purpura, agranulocytosis, neutropenia, pancytopenia, cystic brain hypoplasia.

3 side immune system: reactions of hypersensitivity, including droopy tongue, swollen tongues, swollen skin, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, hives, photosensitivity, pemphigus.

On the side of the shkіri and pіdshkіrnoї kіtkovini: purpura, shkirn_ hanging, sverbizh shkir, erythema multiforme, kropivyanka, bullous pemphigus.

Laboratory indications: impaired tolerance to glucose in patients, ailments with diabetes positive reaction in some tests for the presence of mefenamic acid and its metabolites in liver and liver cells. Increased levels of liver enzymes in blood plasma.

Other Key words: aseptic meningitis, phlegm, drowsiness, sickness, multiple organ failure, hyperthermia.

The term of appurtenance

Wash away the savings

Keep out of the reach of children in the original packaging at a temperature not higher than 25 °C.

Package

10 tablets per contour pack; 2 contour middle packs in packs.

Mefenamic acid is a nonsteroidal, antiseptic, antipyretic, antiviral drug.

stock

1 tab. - 500 mg. mefenamic acid.

Additional ingredients: stearic acid, croscarmellose sodium, methylcellulose, magnesium stearate, potato starch.

Tablets of a gray color with a green color, swollen form with a risk.

Pharmacological authorities

Lie down to antiseptic, analgesic, antipyretic drugs. Spits on the central and peripheral mechanisms of pain sensitivity, relieves the inflammation of the cavity.

Stabilization of clitin membranes, reducing the penetration of the vessel wall. In the inflamed cavity, there is a decrease in the proliferation of clitin and a stimulus for combustion.

Pours into the center of thermoregulation, which has an antipyretic effect. Greater activity of T-lymphocytes, which plays an important role in the function of the immune system, stimulating the generation of interferon, which has an anti-inflammatory effect. Swidko vmoktuєtsya from the slunkovo-intestinal tract, the effect of the drug is in two, or three years. Metabolized by the liver. This drug is administered mainly in the main section, in a small section with feces.

Instructions before freezing

Rheumatoid arthritis;
Postoperative bill;
Rheumatism;
neuralgia;
Mialgiya;
gouty arthritis;
Head bіl;
oncological pain;
When likhomantsi colds zahvoryuvan;
With viral infection;
Tramatic pain;
Periodontitis.

Dosing

Children aged 5-12 years, as a rule, prescribe 250 mg three times a day. Trivality of rejoicing 20 - 60 days.

For children after 12 years of age and mature ailments, the drug is prescribed, as a rule, in the amount of 250-500 mg 3-4 times per doba. If necessary, the dose can be increased to 3000 mg, if positive results are obtained, then the dose can be reduced to 1000 mg. In case of symptomatic healing in different pain syndromes, the term is congested up to one day.

Overdose

This drug may have the power to provoke virazki, as well as erosis of the SHT, rarely buvay - tonic-clonic sudomi.

Symptoms: vomit, bіl at the slut; even more rarely - sloughing bleeding, damage to the arterial pressure, dyspnoea, coma.

Likuvannya: vomit vomit, take sorbent. Forced diuresis. Likuvannya is more symptomatic. In the case of a link with the micrile link of mefenamic acid and albumin, hemodialysis will not be effective.

Pobichna diya

The widest (on the cob of brilliance) side effect is the destruction of the work of the ShKT;
peripheral swelling;
disturbed sleep, increased dramatization;
show dysuric;
discomfort in the galusia of the SHKT;
bіl in the stomach;
tachycardia;
bronchospasm;
damage to the arterial vice;
broken robots;
hanging on the shkіrі, іnоdі - kropiv'yanka.

Contraindication

blood poisoning;
Individual intolerance to the components of the preparations;
With virazkovy ailment;
With the ignition processes of the ShKT;
Damaged robots, livers;
Vagity and period of breastfeeding;
Children of age up to 5 years.

Mefenamic acid with other drugs.

With total congestion of mefenomic acid with metatroxate, the toxic power of metatroxate may increase.

The use of warfarin may reduce the risk of bleeding from the CT.

especially vkazіvki

Mefenamic acid is not a sign of illness, in some cases, surgery was performed on the heart, or severe liver disease (cirrhosis), intestinal perforation.

With special care, the drug is prescribed to people who are ill in summer, as they suffer from epilepsy, asthma, as they may be sick to allergies, from illnesses to diabetes, from broken blood pharynx, from broken livers, and also. For cih ailments, follow the correction of dosing, it is possible to reduce the dose, ce virishu likar.

To reduce the irritation of the mucous membrane of the slough, take the drug at the next hour, or it is possible to reduce the dose.

There are also signs of hanging on the skin, or other signs of side effects, when taking Mefenamic acid and a trace of water.

In case of a trivial treatment with the drug, it is necessary to constantly trim the blood picture, blood work, and also the liver under control.

The drug is prescribed with special care to patients who have an intolerance to acetylsalicylic acid and other antiseptic drugs.

We are ill, as if we are suffering from a broken work of the heart, we are sick of the slut.

For pregnant women, the drug is contraindicated due to the possibility of an hourly closure of the botatal duct.

In the period of breastfeeding, as it is necessary to take the drug, then follow the breastfeeding.

When cured by transport means, the drug can be injected into the frequency of reactions, so for an hour the passage of the drug will be eliminated from the cured by transport.

Children up to 5 years of age were given the drug.

Taking an hour with antacids may increase plasma concentrations of mefenamic acid.

Taken together with other non-steroidal drugs may ameliorate the risk of side effects of CHT.

Such preparations as: thiamin, antithrombotic drugs, similar to phenothiazine, pyridoxine can help with mefenamic acid.

Analogues

Aponil;
Artrum;
Voltaren;
Maw;
Ketonal;

Price

In Ukraine

Capsules 250 mg No. 20 - 18 UAH.
Capsules 500 mg No. 29 - 29 UAH.

For residents of Russia

Capsules 250mg. No. 20 - 120 rubles.

Prescription term for the drug: in a dry place at temperatures up to 25 degrees. - 5 years.

Name: MEFENAMIC ACID-DARNITSIA, Darnitsa

Pharmacological power. Mefenamic acid - NSAIDs. The mechanism of protizapalnye dії razumovaniya mozhlivіst prinіchuvat synthesis of mediators of inflammation (prostaglandins, serotonin, kinіnіv etc.), reduce the activity of lysosomal enzymes, which take part in the inflammatory reaction. Mefenamic acid normalizes the protein ultrastructure and cell membranes, changes the penetration of vessels, disrupts the processes of oxide phosphorylation, inhibits the synthesis of mucopolysaccharides, galmuic proliferation of cells in the inflamed cavity, improves the resistance of cells and stimulates wounds. The antipyretic activity is associated with the possibility of galvanizing the synthesis of prostaglandins and injecting them into the thermoregulation center.
Mefenamic acid stimulates the release of interferon.
In the mechanism of pain relief, in order of influx on the central mechanism of pain sensitivity, the original role in playing the muscles, injecting into the middle of the inflammation and the possibility of galmuvati algogenes (kinin, histamine, serotonin).
After taking internally mefenamic acid, it is easy to drink and soak thoroughly in the herbal tract. Cmax in blood plasma is determined in 2-4 years after taking it, the blood level is proportional to the dose taken. Equally important concentration (20 mcg / ml) is assigned for 2 doses of ingestion (1 g 4 times per dose). Contacted by 90% of blood albumin. In the liver, it metabolizes by way of oxidation, hydrolysis, glucuronidation. T½ becomes 2-4 years. Excreted in the body in an unchanging way in the appearance of metabolites mainly from the section (67% dosing) and feces (20-25%).

Warehouse and release form

tab. 500 mg kont. middle. pack. #10 #20

No. UA/7015/01/01 dated 10/19/2012 to 10/19/2017

Indication

GRVI and the flu.
Pain of low and medium intensity: m'yazovy, suglobovy, traumatic, dental, head pain of different etiology, post-operative and post-slyapological pain.
Primary dysmenorrhea. Dysfunctional menorrhagia, including those caused by congestion of intrauterine contraceptives - due to the presence of pathology of the pelvic organs.
Illumination of the musculoskeletal apparatus: rheumatoid arthritis, rheumatism, Bechter's disease.

Zastosuvannya

vikoristovuyut internally. We will grow up and children will be prescribing 250-500 mg 3-4 times for doba for 12 years. For indications and with good tolerance, the additional dose should be increased to a maximum of 3000 mg, after reaching a therapeutic effect, the dose should be reduced to 1000 mg per dose.
For children aged 5-12 years - 250 mg 3-4 times per day.
The drug should be taken after taking it with milk. The course of healing in case of ill-healthy swamps can be taken from 20 days to 2 months and more. With pain syndrome, the course of treatment is up to 7 days.

Contraindication

hypersensitivity to components of faces; virazka schlub and twelve-fingered intestines; chronic fuses of ill-health of SHKT; sickness of nirok and hematopoietic organs; period of pregnancy and breastfeeding; Vіk to 5 roіv.

Side effects

from the side of the shlunkovo-intestinal tract: epigastric dilatation, anorexia, liver pain, nausea, flatulence, vomiting, intestinal bleeding, dyspepsia, constipation, diarrhea, elevation of hepatic enzymes in blood plasma.
From the side of the cardiovascular system: AH, arrhythmia, in infrequent seizures - congestive heart failure, peripheral swelling, syncope.
From the side of the dichal system: dyspnea, bronchospasm.
From the side of the sechovivid system: dysuria, cystitis, impaired function of nirok, albuminuria, hematuria, oliguria or polyuria.
From the side of the blood system: anemia, delayed bleeding, eosinophilia, leukopenia, thrombocytopenia.
From the side of the CNS: drowsiness or sleeplessness, weakness, drativity.
From the side of the organs a little: dzvіn u vuhah, ruined by the dawn.
From the side of the shkiri: allergic reactions; shkirn_ visipannya, sverbіzh, nabryak disguise.

especially vkazіvki

Prescribe the drug with care if you are ill, if you have a history of allergic reactions to acetylsalicylic acid and other non-steroidal anti-inflammatory diseases.
We prescribe the drug with care for the presence of acute heart failure, as well as with a history of dyslexia or duodenal ulcer in anamnesis.
Vikoristannya pіd hour vаgіtnostі аbo boduvannya chest. The drug is contraindicated in the period of pregnancy through the temporal hemorrhage of the anterior closure of the botatal duct. If necessary, stosuvannya likіv during lactation, breastfeeding should be given.
Possibility to add to the speed of the reaction during keruvannya transport facilities and robots with other mechanisms. The drug can be added to the severity of reactions during treatment by transport means and robots with mechanisms that require increased attention.
Children. The drug is contraindicated for children up to 5 years of age.

Interaction

opioids analgesics, antithrombotic agents, vitamin K antagonists, pyridoxine, thiamin, phenothiazine-like drugs can be treated with an injection of mefenamic acid. With total vicarious mefenamic acid and methotrexate, the toxic effects of the remainder are exacerbated. In case of one-hour treatment with warfarin, there is a risk of mucosal-intestinal bleeding.
With total vicarious mefenamic acid and antacids, the Cmax of mefenamic acid in blood plasma rises and the AUC increases.
One hour of controversy with other non-steroidal anti-spasmodic cases, the greater likelihood of the appearance of side effects from the side of the SCT.

Overdose

symptoms: pain in epigastric dilatation, boredom, vomiting, drowsiness. In severe depressions - sloughing-intestinal bleeding, dyspnoea, arterial hypertension, mimicking of other groups of mucus, coma.
Likuvannya. Specific antidote daily. Washing the sluice with a suspension of activated water. Pіdluzhuvannya section, forcing diuresis. Symptomatic therapy. Hemosorption and hemodialysis are of little effect due to the microbinding of mefenamic acid with blood proteins.