You can take bisoprolol. Bisoprolol. Concor and yoga are cheap analogues. With ischemic heart disease

For 1 tablet:

dosing 2.5 mg :

speech active: bisoprolol fumarate 2.5 mg;

additional speeches: microcrystalline cellulose 93.5 mg, corn starch 43.7 mg, croscarmellose sodium 2.9 mg, magnesium stearate 1.5 mg, silicon dioxide coloid 1.4 mg;

shell:polyvinyl alcohol (polyvinyl alcohol 1.80 mg, titanium dioxide 1.03 mg, macrogol 0.91 mg, talc 0.67 mg, barvnik zhovtium oxide 0.09 mg) 4.5 mg;

dosing 5 mg:

speech active: bisoprolol fumarate 5.0 mg;

additionalatspruce speeches: microcrystalline cellulose 91.0 mg, corn starch 43.7 mg, croscarmellose sodium 2.9 mg, magnesium stearate 1.5 mg, silicon dioxide coloid 1.4 mg;

shell:polyvinyl alcohol (polyvinyl alcohol 1.8000 mg, macrogol 0.9090 mg, titanium dioxide 0.8770 mg, talc 0.6660 mg, bay bark zhovtium oxide 0.2475 mg, barvnik bark black oxide 0.0005 mg) 4 mg;

dosing 10 mg:

speech active: bisoprolol fumarate 10.0 mg;

additional speeches: microcrystalline cellulose 150.4 mg, corn starch 73.0 mg, croscarmellose sodium 4.9 mg, magnesium stearate 2.4 mg, silicon dioxide coloid 2.3 mg;

shell:polyvinyl alcohol 2.80 mg, titanium dioxide 1.75 mg, macrogol 1.41 mg, talc 1.04 mg) 7.0 mg.

Dosage 2.5 mg: Round, biconvex tablets with a ridge and bevel, covered with a plaid shell in a light yellow to yellow color. On the transverse cut, the kernel has a white to yellowish-white color.

Dosage of 5 mg: Round, biconvex tablets with a ribbed and chamfered, covered with a plaid shell in yellow to dark yellow color. On the transverse cut, the kernel has a white to yellowish-white color.

Dosage of 10 mg: Round, biconvex tablets, covered with a plaid shell of a white color. On the transverse cut, the kernel has a white to yellowish-white color.

Bisoprolol is a selective beta 1-adrenoblocker, without ocular sympathomimetic activity, does not have a membrane stabilizing effect. As for other beta-1-blockers, the mechanism of action in arterial hypertension is not clear. At the same time, it appears that it reduces the activity of renin in plasma, changes the demand of the myocardium in the blood, and increases the heart rate (HR). Repair antihypertensive, antiarrhythmic and antianginal disease. Blokuyuchi nevisokih in doses of beta 1 -adrenoceptor sericite, zmenshuє stimulovane kateholamіnami utvorennya tsiklіchnogo adenosine monophosphate (cAMP) of adenosine triphosphate (ATP), znizhuє vnutrіshnoklіtinny Strum іonіv kaltsіyu (Ca 2+), nadaє negatively chronotropic, prignіchuє provіdnіst that zbudlivіst, znizhuє atrіoventrikulyarnu (AV ) conductivity.

If the therapeutic dose is transferred, beta 2-adrenergic blocking may occur. In the first 24 years, the acute peripheral sudinal opir on the cob of drug ingestion increases (as a result of a reciprocal increase in the activity of alpha-adrenergic receptors and the use of stimulation of beta 2-adrenergic receptors), after 1-3 doses it turns to the output value, and when trivial zastosuvanni- Decrease.

Antigіpertenzivny efekt pov'yazany іz zmenshennyam hvilinnogo ob'єmu krovі, simpatichnoї stimulyatsії sudin peripheral character, znizhennyam aktivnostі simpatoadrenalovoї system (SAS) (Got the great significance for patsієntіv іz vihіdnoyu gіpersekretsієyu renіnu) vіdnovlennyam chutlivostі in vіdpovіd on znizhennya arterіalnogo vise (AT) is the vplivom to the central nervous system. (CNS). With arterial hypertension, the effect develops in 2-5 days, stable action is seen in 1-2 months.

Anti-anginal effect of confusion due to changes in myocardial demand in acidity due to decreased heart rate, a slight decrease in speed, decreased diastole, decreased myocardial perfusion.

Antiaritmіchny efekt obumovleny usunennyam arrhythmogenic faktorіv (tahіkardії, pіdvischenoї aktivnostі simpatichnoї nervovoї system zbіlshenogo vmіstu cAMP arterіalnoї gіpertenzії) zmenshennyam shvidkostі spontaneous zbudzhennya sinus that ektopіchnogo vodіїv rhythm i upovіlnennyam AV assistants (perevazhno antegrade that in the AV vuzol) that for dodatkovimi Shlyakhov.

In case of zastosuvanni in medium therapeutic doses, on administration of non-selective beta-adrenoblockers, fewer expressions influx on organs, but beta 2 - adrenoreceptors (subcutaneous malaria, skeletal mucosa, smooth muscles of peripheral arteries, bronchi and uterus) ) in organisms; The virulence of atherogenic disease is not related to that of propranolol.

Vsmoktuvannya . may be partially (> 90%) absorbed from the intestinal tract. Its bioavailability after insignificant metabolism in the "primary passage" through the liver (at a rate of approximately 10-15%) becomes approximately 85-90% after ingestion. This does not affect the bioavailability of bisoprolol. demonstrates linear kinetics, moreover, the concentration in blood plasma is proportional to the administered dose in the dose range of 5 to 20 mg. The maximum plasma concentration is reached in 2-3 years.

Rozpodіl. rozpodіlyaєtsya dosit widely. Volume rose to become 3.5 l/kg. The binding from blood plasma proteins reaches approximately 35%; there is no blood ingestion of bisoprolol by blood cells.

Metabolism. metabolized along the oxide route without further conjugation. All metabolites may have a strong polarity and be produced by nirks. The main metabolites that are found in blood plasma do not show pharmacological activity. Data taken from the results of experiments with human liver microsomes in vitro, show that it is metabolized in the first place for the help of the CYP 3A 4 isoenzyme (about 95%), and the CYP 2D 6 isoenzyme plays only a small role.

Vivedennya. The clearance of bisoprolol is consistent between administration via nirk in apparently unchanged speech (about 50%) and oxidized in the liver (about 50%) to metabolites, which are then also excreted by nirk. The total clearance of bisoprolol is to become 15.6±3.2 l/year, and the clearance of nirk is up to 9.6±1.6 l/year. The period of administration of bisoprolol should be 10-12 years.

Oskіlki vyvedennja may є mіsce nіrkakh і pіntsі іvnoy miroy, patsієnnymi porushennym ї ї pіnії аbo iz nirkovuyu insufficiency dose correction is not necessary. Pharmacokinetics of bisoprolol is linear and does not lie in vіku.

In patients with chronic heart failure (CHF), plasma concentrations of bisoprolol were observed, and the duration of drinking was more similar to that of healthy volunteers.

Arterial hypertension;

Ischemic heart disease: prevention of attacks of stable angina pectoris;

Chronic heart failure.

Increased sensitivity to drug components and other beta-blockers;

Gostra heart failure and CHF at the stage of decompensation, which will require inotropic therapy;

cardiogenic shock;

collapse;

AV block II-III stage, without a pacemaker;

Sinoatrial blockade;

Syndrome of weakness of the sinus node;

Bradycardia (heart rate up to the cob less than 60 bpm);

Severe arterial hypotension (systolic arterial pressure less than 100 mm Hg)

Cardiomegaly (no sign of heart failure);

Severe forms of bronchial asthma and chronic obstructive ailment legenia (COPD) in history;

Virazhenі damage to peripheral blood circulation;

Raynaud's syndrome;

Metabolic acidosis;

Pheochromocytoma (without one-hour blockage of alpha-blockers);

One-hour administration of monoamine oxidase (MAO) inhibitors (with the exception of type B MAO inhibitors);

Vіk till 18 roіv (efficiency and safety have not been established).

Psoriasis, depression (including history), blood diabetes (may mask symptoms of hypoglycemia), allergic reactions (history), bronchospasm (history), desensitization therapy, Prinzmetal's angina, AV block QC) less than 20 ml / min); severe damage to liver function; hyperthyroidism, summer vіk, restrictive cardiomyopathy, congenital heart valve or heart valve disease with severe hemodynamic damage, CHF with myocardial infarction for the remaining 3 months, strict diet.

Vagity

Bisoprolol does not have direct cytotoxic, mutagenic and teratogenic effects, but it does have pharmacological effects, which can cause a lot of fluctuations in vaping either on the pregnancy or on the newborn. Call beta-blockers to reduce placental perfusion, which leads to fetal growth, intrauterine fetal death, fetal death, or early folds. In the fetus, that neonatal child can cause pathological reactions, such as intrauterine growth retardation, hypoglycemia, bradycardia.

Bisoprolol does not zastosovuvaty pіd hour vagіtnostі, zastosuvannya can be in that case, as a misfortune for the mother outweighs the risk of development of side effects in the fetus and/or child. In that case, if the drug is considered as necessary, there should be blood flow in the placenta and mother, and also to watch for the growth and development of the possible child, in case of appearance of non-negligible manifestations of pregnancy and/or the fetus, take an alternative method of therapy. It is very important to keep the newly-born post-pologiv. Symptoms of hypoglycemia and bradycardia, as a rule, are blamed for the prolongation of the first 3 days of life.

The period of breastfeeding

There is no milk given to bisoprolol in breast milk. This drug is not recommended for women under one hour of breastfeeding.

If necessary, the drug should be taken during the period of breastfeeding, breastfeeding should be administered.

Phenytoin with intravenous administration, use for inhalation anesthesia (similar to carbohydrates) increases the severity of cardiodepressive disease and the decrease in arterial pressure.

Clearance of lidocaine and xanthines (crim theophylline) may be reduced in association with possible shifts in plasma concentrations, especially in patients with cob shifted clearance of theophylline and chicken infusion.

The control over the state of patients, if they take the drug, is responsible for including the control of heart rate and AT, the ECG, the determination of the concentration of glucose in the blood of patients with with diabetes(1 time for 4-5 months). In patients with a frail age, it is recommended to stitch for the function of nirok (1 time for 4-5 months).

Next, teach the patient the method of pacing heart rate and instruct about the need for medical consultation with a heart rate of less than 60 beats / min.

Patients who are covered with contact lenses should be treated for changes in the production of the lacrimal rind against the background of the preparation.

It is possible to increase the severity of the reaction of increased sensitivity and the duration of the effect in the presence of significant doses of epinephrine (adrenaline) on aphids of a severe allergological history.

In the case of the need for a planned surgical treatment, the drug should be taken 48 years before the general anesthesia. If the patient has taken the drug before surgery, then he should choose a drug for general anesthesia with a minimally negative inotropic effect.

Reciprocal activation of the bulging nerve can be given by intravenous atropine (1-2 mg).

Lіkarski Dresses, Yaki Visentant depot Catecholamіn_v (in that numeric), you can ask for a beta-adrenobloclocator, that Pazієntti, Yaki, T. Podnannya Lіkarskiy Plugіv, Moon Bethi Pіd postіinniki Likekari on the subject of the prieved zinage of an arterial study by Abbo Bradikardії.

Patients with bronchospastic ailments can, with caution, be given cardioselective beta-blockers in case of intolerance and / or ineffectiveness of other hypotensive diseases. On aphids, taking beta-blockers in patients with concomitant bronchial asthma can be treated with dyhal pathways. With overdose of such patients, the risk of development of bronchospasm is caused.

In cases of increased bradycardia (heart rate less than 50 beats / min), pronounced decrease in AT (systolic AT less than 100 mm Hg), AV blockade, it is necessary to change the dose or treat it.

It is recommended to initiate therapy with the drug in case of development of depression. It is not possible to abruptly interrupt the bliss through the unsafe development of severe arrhythmias and myocardial infarction. The administration of the drug is carried out step by step, reducing the dose for 2 days and more (reduce the dose by 25% for 3-4 days).

Follow up the drug before reaching blood concentrations of catecholamines, normetanephrine, vanillinmandelic acid, antinuclear antibody titers.

The effectiveness of beta-adrenergic blockers is lower in Kurtz.

Zastosuvannya drug does not affect the health of keruvati transport facilities Zgidno with the results of follow-up in patients with IXC. However, in the aftermath of individual reactions, the structure can be damaged by transport means or by technically folding mechanisms. At the end of the day, I especially respect the cob of joy after changing the dose, as well as with one-hour alcohol intake.

Tablets, coated with velvet, 2.5 mg, 5 mg and 10 mg.

10 tablets each in a contoured middle package with polyvinyl chloride slick and aluminum foil lacquered.

100 tablets in a jar of polymer vibrating, made from polypropylene and corked with a lid from polypropylene or a jar of polymer, prepared with a low-pressure polyethylene and sealed with a lid, prepared from a sum of polypropylene in a high grip and a polyeth- ylene in a low vise.

3, 5 or 10 contour middle packs or 1 can of polymer together with instructions from the stop is placed next to a pack of cardboard.

In a dry place, protected from light, at a temperature not higher than 25 °C.

Take care of the place inaccessible to children.

Zagalnі characteristics. Stock:

Pharmacological authorities:

Indication before zastosuvannya:

Important! Let's get to know the exuberance

Method of stosuvannya that dose:

Features of zastosuvannya:

Pobichna diya:

Interaction with other medical care:

Contraindication:

Overdose:

Wash the savings:

In a protected species, light is not higher than 25 °C at normal temperatures. Take care of the place inaccessible to children.

Wash the permits:

For the recipe

Package:

Tablets, coated with a plaited shell, 2.5 mg, 5 mg and 10 mg. 10, 30 tablets each in a contour, middle package with polyvinyl chloride and aluminum foil, lacquered. For 10, 20, 30, 40, 50, 60 or 100 tablets in polymeric jars for medicinal purposes.
One bank or 1, 2, 3, 4, 5, 6, 8 or 10 contour middle packs at once with instructions from the stop is placed in a pack of cardboard.

Bisoprolol is a popular medicinal drug from the group of beta-blockers, which is widely used for the treatment of cardiovascular disease and hypertension. The drug may affect protishemichnu diyu, allowing to reduce the rate of arterial pressure and normalize the frequency of heart rates. Bisoprolol blocks the production of adrenaline, which provokes an increase in the arterial pressure.

Particularly unsafe is the high pressure for patients of the senior age group. Such a camp is no less signifi- cantly aggravated, more self-consciously, and it threatens with bloody brains. Current drug concerns (Bisoprolol and yogo analogues) allow for a short term problem and bring all indications back to normal. The drug Bisoprolol inclusions before the transfer of life important medical benefits and is widely used in the health care system.

Dia drug

Bisoprolol is a selective beta-blocker. Repair hypotensive, antianginal (protischemic) and antiarrhythmic disease. The main speech agent is bisoprolol fumarate, which blocks adrenaline receptors, improves internal strum ions, changes the heart rate, reduces the demand of the myocardium in the sourness and reduces anxiety. At high doses, the drug blocks the blockade of beta2-adrenergic receptors in the smooth mucous membranes of the sudina and bronchi.

Bisoprolol reduces the penetration of clitin membranes, as a result, the strum of calcium ions in the clitins of smooth tissues is often blocked, and the tone of the arteries decreases. Zavdyaki tsomu changes the peripheral vessel support, decreases the arterial pressure and the pressure on the heart m'yaz. The antiarrhythmic and antiarrhythmic effects are due to the increase in the conductivity of the electrical impulse, which allows to reduce the frequency of the heart rate and improve the blood circulation of the myocardium.

When administered, Bisoprolol is easily absorbed from the SHT, while taking it does not interfere with the whole process. The required therapeutic concentration is established after 1-2 years, about 30% of the drug binds to plasma proteins. Speech is active in a small amount of time to pass through the placental barrier and be seen with breast milk. Up to half of the dose taken is metabolized in the liver, in the body the drug is almost completely excreted from the body, an insignificant amount is seen from the stomach.

Warehouse and release form

The drug Bisoprolol is released in the form of tablets in three doses, which can be 2.5 mg, 5 mg or 10 mg of the active ingredient + additional speech. Round, biconvex tablets coated with yellow husk beige color on the evil stench, a white color is cast. Pack 10 pieces for commercial contour blisters or 30 pieces for polymer cans or bottles.

In pharmacies, you can buy the usual Bisoprolol, so it’s different:

• Bisoprolol prana
• Bisoprolol tiva

These preparations are practically not used in any way, one in one, take 5 mg or 10 mg of bisoprolol fumarate and are allowed in packages that take in 10 to 100 pieces of tablets.

Analogues

Bisoprolol has a lot of structural analogs of fluffy speech. The most popular of them:

• Concor
• Concor Core
• Coronal
• Niperten
• Biocard
• Tirez
• Aritel Core

Why does it have an analogy to the original? Take two preparations for matching: Bisoprolol and Concor. Having offended the likarsky sob to avenge one and the same active intoxicant speech - bisoprolol fumarate and may be identical to the therapeutic one.

Rіznitsya is less for the picker. Bisoprolol is a commercial drug, and Concor is created and patented by German pharmacists. Mayuchi however, the mechanism of efficiency and efficiency, medical care is worth more than the price. Bisoprolol Concor є expensive medical care, the average price per pack is about 230 rubles.

In the pharmacy, Bisoprolol tablets can be bought inexpensively. Packing Bisoprolol 5mg (30 pcs) cost 26 rubles, Bisoprolol prana (30 pcs) can be ordered for 50 rubles, Bisoprolol tiva (30 pcs) - 90 rubles.

Indication before zastosuvannya

Bisoprolol is widely used for the treatment of cardiovascular pathologies: angina pectoris (ischemic heart disease), with impaired cardiac rhythm (sinus tachycardia) and arterial hypertension.

Krym tsgogo, the drug is prescribed for the treatment of arrhythmia, provoked by mitral valve prolapse or thyrotoxicosis, extrasystoles (two and supratachular). Bisoprolol is known to be widely used in chronic heart failure in combination with other medical conditions (cardiac glycosides, sechogennye drugs, inhibitors).

Instructions for administering and dosing the drug

Zgidno z іnstruktsiєyu іz zastosuvannya Bisoprolol, the drug should be taken early, on a hungry day or at midnight. Tablets need to be crushed flat, not rotting, and washed down with a small amount of water. Pochatkova dose become 5 mg once a day. If it is necessary, then the qiu dose can be increased to 10 mg per doba.

The maximum dose that is taken for doba is not guilty of overdosing 20 mg if the drug is well tolerated. For the exaltation of patients of a frail age, there is no need for a corrected dose. In patients with severe functional impairment, the maximum supplementary dose should not exceed 10 mg. One of the advantages of the drug is those who, in order to achieve the desired therapeutic effect, should take the recommended dose of Bisoprolol once a day.

Patients with severe or severe chronic insufficiency Bisoprolol should be prescribed in that case, if they become overwhelmed with a stable stretch of the remaining 6 days. With this therapy, it was not possible to correct it for 2 days before taking Bisoprolol. For the treatment of such ailments, the drug should be used in combination with diuretics, cardiac glycosides, ACE inhibitors.

The standard treatment regimen for patients with chronic heart failure is to take Bisoprolol at an initial dose of 1.25 mg, and then take it once for the first day of treatment. For another hour of therapy, increase the dose of the drug to 2.5 mg per dose. On the third day, the additional dose should be 3.75 mg, from the fourth to the eighth day, take 5 mg of lyca per day. From the 8th to the 12th day of the day, the dose should be reduced and adjusted to 7.5 mg, after the 12th day of the day, the maximum possible dose is prescribed, so that it becomes 10 mg per dose.

Depending on how the patient tolerates the drug, the doctor may change the dosing regimen on an individual basis. Under the hour of therapy, the fahivets is obliged to keep watch over the camp of the patient and to control indications of arterial pressure and the frequency of the heart rate. In mild cases, if drug intolerance is indicated or symptoms of heart failure worsen, the dose of the drug should be reduced.

With an overdose of the drug, a sharp decrease in pressure, development of bradycardia, bronchospasm and a dangerous increase in heart rates can occur. In such cases, treatment with the drug should be nego- nally applied. To the ailing man, to slacken the passage of the slug, prescribe a reception activated vugill and spend other merry visits.

Bisoprolol has shown its effectiveness in the treatment of arterial hypertension. Stopping the drug allows you to control the arterial pressure, not only in calm, but also in case of physical advantages. With any therapeutic use of the drug, the stability and equal stretch of the doby is considered.

Under the hour of therapy with the drug, monitoring of arterial pressure in patients was carried out. The investigation confirmed that Bisoprolol retained hypertensive activity at the same level both day and night. This particularity of the drug is especially important to reduce the increased nighttime pressure, which allows to change the hypertrophy of the left heart duct.

Approximately 80% of patients who suffer from chronic hypertension reported a decrease in the chance of achieving a stable positive result with a single additional dose of bisoprolol in the total of 5-10 mg. The effect of treatment with the drug is stable and, for a long time, allows saving normal indications of arterial pressure.

Contraindication

Bisoprolol contraindications to zastosuvannya in such camps:

The drug cannot be used together with MAO inhibitors, with sinus node weakness syndrome, lactose intolerance, lactase deficiency. Bisoprolol is prescribed with special care for hepatic and neurological insufficiency, circulatory diabetes, thyrotoxicosis, psoriasis, depression.

Bisoprolol for pregnancy

During pregnancy and lactation, bisoprolol is not recommended to be congested. The drug vikoristovuyut less for the indications of the doctor and in quiet depressions, if the mother's grief for the mother is due to the risk of development of unfavorable traits in the fetus. The active speech of the drug is able to penetrate through the placental barrier and the consequences of damage to the intrauterine development of the fetus: growth inhibition, hypoglycemia.

Vicoristanny likіv maє buti was administered no less than 72 years before the transfer of the pologіv, the shards of the drug can cause an increase in the pulse and an aggravation of the breathing of the newborn. Active ingredient faces are seen with breast milk, for the need for the mother's glee during lactation, breastfeeding is given, the child is translated into piece sumish.

Pobichna diya

Ingestion of bisoprolol can cause various side effects from the side of the body and systems of the body.

• Central nervous system may respond to mild headaches, weakness, drowsiness, confusion, sleep disturbance. In solitary moods, confusion of memory, short-term loss of memory, symptoms of asthenia, tremor, hallucinations are indicated.
• From the side of the cardiovascular system may cause such damage: palpitations, arrhythmias, sinus bradycardia, pain in the breasts, increased symptoms of heart failure, a sharp decrease in arterial pressure. In even more lonely depressions, important, life-threatening conditions were noted: damage to the peripheral circulation and myocardial conduction, transverse blockade, which threatens the heart with a spike. In such situations, there is a need for indispensable medical assistance.
• From the side of the organs a little the patients predicted damage to the dawn, that dryness ill-natured in the eyes, development of conjunctivitis.
• From the side of the shlunkovo-intestinal tract dryness in the mouth, nausea, vomiting, pain in the stomach, change in taste, diarrhea and constipation, darkening of the cross section, yellowness of the skin.
• From the side of the dichal system patients complain of nasal congestion, difficulty breathing,
• from the side endocrine system in patients with diabetes mellitus, symptoms of hypoglycemia or hyperglycemia may appear.

The use of the drug can provoke the development of allergic reactions (cropovyanka, sverbizh shkiri) or dermatological manifestations (scarring of the skin, psoriasis-like reactions and worsening of symptoms of psoriasis, increased sweating).

Among the other unfavorable symptoms, physicians indicate a change in blood indicators, pain in the back, and a decrease in potency. Razka administration of the drug can provoke an increase in arterial pressure and attacks of angina pectoris.

It is more accurate to get rid of such complication to the exact dosing of that scheme of healing, recognized by the doctor. Fahivets pidbere the most optimal course possible contraindications However, the severity of the illness Bisoprolol cannot be overcome for self-admiration, uncontrolled drug intake without consultation with a doctor can cause serious complications.

Medical interaction

Overnight exposure to the drug with allergens, which are used for immunotherapy, can lead to severe allergic reactions, even to anaphylactic shock. Diagnostic iodine tests for intravenous administration also increase the risk of developing anaphylactic reactions. The drug can be weakened by a one-hour intake from non-hormonal anti-inflammatory drugs.

Chronic congestion of bisoprolol with diuretics and antihypertensive drugs can lead to a sharp decrease in arterial pressure. It is not recommended to combine bisoprolol with calcium antagonists, reserpine, nifedipine.

especially vkazіvki

Treatment with bisoprolol will require regular medical care. Fahivets is responsible for controlling the frequency of heart rates, arterial pressure, ECG, instead of glucose in the blood in patients with diabetes mellitus, liver function.

Treat yourself with the drug Trivale. The patient is not guilty of independently changing the recognition of dosing, or arbitrarily interrupting the course of treatment. Rizka vіdmіn drug can provoke negligence sládnennya, to that lіkuvannya zakіvannja zakіvnchuyut step by step with step-by-step dose changes. This rule is especially relevant for patients with chronic heart failure and damage to the coronary vessels.

In the case of stagnation of Bisoprolol, it can provoke the development of luscious lichen, or lead to psoriatic hanging on the skin. Doctors are ahead of what patients have to burn, the effectiveness of the drug is reduced, and in the category of ailments, as they are covered with contact lenses, there may be a change in the vibration of the mucosal tract. With the development of depressive states, likuvannya should be pinned down.

During the period of treatment with Bisoprolol, special precautions should be taken when caring for transport means and vikonannі robit, caused by a crippled nezabezpeka.